The SMART digest (previously called FLASH) works amazingly well for digesting commercial antibodies that...you know...are used cause they happen to work perfectly for mass spectrometry.... I've got files with 100% coverage off these kits from a couple of different antibodies. Fast, perfect, reproducible.
But...the question has been...does it work for other proteins?!?!
Check this out!!
Consensus? Yeah! It works for all sorts of proteins! Including ones that are hard to digest by other methods.