Today's issue of Science and Science signaling have a special emphasis on Cancer Genomics. Most of the articles, unfortunately, won't be available to actually read for a couple of days, but I did manage to find something interesting. The cBioPortal at MSK is a database that looks through a large number of published genomics data sets and gives you information on whether your gene(s) of interest have been previously implicated in any forms of cancer.
For example, a study that I did during one of my postdoctoral fellowship implicated a novel phosphorylation site on integrin alpha 4 (ITGA4) in the mechanism of action of a proprietary drug we were working with. Input ITGA4 into cBioPortal and you get this nifty chart:
This shows that ITGA4 mutations, amplifications, and deletions have all been implicated in these forms of cancer. This would have been a great slide for our monthly progress reports! At least we have access to this great database now! You can find more on it (and a tutorial) at the MSK website.
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