Tuesday, February 14, 2012

Today's Lunch Read: Quantitative Proteomics Reveals New Insights into Erythrocyte Invasion in Plasmodium Falciparum

Today's lunch time fun was an article that came out in this week's Molecular and Cellular Proteomics.  The group is from Nanyang Tech in Singapore and you can find the abstract here.
The title of my post describes the paper pretty well.  They used a combination of transcriptional and quantitative proteomics (iTRAQ) to interrogate some P.f. cultures that were treated with neuraminidase.
The iTRAQ proteomics samples were analyzed with a QStar Elite.
The highlight of the paper is the two very nice tables of the up- and down- regulated proteins found by iTRAQ (roughly 75-100) when the cells are treated with this agent.
While this paper is a nice solid study, it does a good job of highlighting how little we really know about this organism, as well as how relatively poorly the genes/proteins are currently annotated.  

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